The European Commision have published a brief report on the SmartNanoTox project, focusing on the recent results on the prediction of lung inflammation as reported in Advanced Materials<\/a>. The report can be accessed via the CORDIS<\/a> website.<\/strong><\/p>\n SmartNanoTox consortium proposed a mechanism-aware approach to assessment of nanomaterial toxicity based on the detailed understanding of all key interactions between the nanomaterial and the organism from the initial contact to the adverse outcome. The recent publication in Advanced Materials journal<\/a> illustrates this novel approach in action. Using high resolution imaging, omics, pathway analysis, and computer simulations the team has identified of a vicious cycle of nanomaterials uptake, excretion and quarantining by different cell types in the lung can result in chronic lung inflammation.<\/p>\n The paper is outstanding in many aspects. It accumulates a tremendous research effort invested by the project team over four years. The interdisciplinary team lead by Tilen Kokli\u010d and Janez \u0160trancar of Jozef Stefan Institute (Ljubljana) and Tobias Stoeger Helmholtz Zentrum (Munich) includes biologists, toxicologists, chemists, physicists, materials scientists form 8 labs across Europe, China and Canada. The associated in vivo, in vitro and in silico data are presented in over 180 figures, 42 videos and 12 tables. Based on the collected results, in accordance with the SmartNanoTox assessment paradigm, the chronic adverse outcome can be predicted for new nanomaterials without a need for in vivo animal exposure experiment but with only in vitro tests and computational modelling. This demonstration of power of the mechanistic approach to toxicology opens new perspectives in animal-free materials testing and implementation of safety-by-design approach in nanotechnology.<\/p>\n<\/span><\/strong><\/p>\n
Advanced Materials frontispiece poster<\/strong><\/h5>\n
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<\/p>\nSmartNanoTox: Advancing commercial development of safe nanomaterials webinar, 30 September 2020<\/strong><\/h5>\n
Agenda<\/strong><\/h6>\n
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