SMART TOOLS FOR GAUGING NANO HAZARDS

 

A definitive conclusion about the dangers associated with human or animal exposure to a particular nanomaterial can currently be made upon complex and costly procedures including complete NM characterisation with consequent careful and well-controlled in vivo experiments. A significant progress in the ability of the robust nanotoxicity prediction can be achieved using modern approaches based on one hand on systems biology, on another hand on statistical and other computational methods of analysis. In this project, using a comprehensive self-consistent study, which includes in-vivo, in-vitro and in-silico research, we address main respiratory toxicity pathways for representative set of nanomaterials, identify the mechanistic key events of the pathways, and relate them to interactions at bionano interface via careful post-uptake nanoparticle characterisation and molecular modelling. This approach will allow us to formulate novel set of toxicological mechanism-aware end-points that can be assessed in by means of economic and straightforward tests. Using the exhaustive list of end-points and pathways for the selected nanomaterials and exposure routes, we will enable clear discrimination between different pathways and relate the toxicity pathway to the properties of the material via intelligent QSARs. If successful, this approach will allow grouping of materials based on their ability to produce the pathway-relevant key events, identification of properties of concern for new materials, and will help to reduce the need for blanket toxicity testing and animal testing in the future.

This project has received funding from the European Union’s Horizon 2020 research and innovation programme under grant agreement No. 686098

 

For further information, please view the SmartNanoTox Brochure

EVENTS

  • March 9th 2020: Spring Meeting and General Assembly, Danish Society for Toxicology and Pharmacology, Københavns Universitet, Denmark (slides)
  • December 16th-18th 2019: OECD WPMN Meeting on Advanced Materials, Paris, France (slides)
  • November 27th-28th 2019: Symposium Occupational Exposure to Engineered Nanomaterials and Lung Health, Oslo, Norway
  • October 28th-30th 2019: First South African-French Workshop on nanotechnologies, University of Johannesburg, Republic of South Africa
  • October 21st-23rd 2019: CECAM workshop WaterEurope: Multiscale simulations and coarse-grained models for water and aqueous systems, Lausanne, Switzerland
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Project Partners

This project has received funding from the European Union’s Horizon 2020 research and innovation programme under grant agreement No 686098.