Join the SmartNanoTox project to discover the smart approach to understand respiratory toxicity pathways for nanomaterials – 29 November 2018 15:00 CET

The project brings together in silico, in vivo and in vitro methods, linked to systems biology, to create a practical set of tests and intelligent QSARS for materials producers. This open webinar presents project aims, scientific work and outcomes to date plus how this can impact your work in nanomaterials or respiratory toxicity.

Registration is free of charge.

You can sign up here: https://www.eventbrite.com/e/meet-smartnanotox-tickets-50587132475

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Exploring the Nano-World at Imperial College Festival 2018

SmartNanoTox project was highlighted during on the 28th and 29th of April this year.

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Nanotechnology Industries Association

Five SmartNanoTox members (University College Dublin, Dassault Systemes Biovia Ltd., Vitrocell Systems, Finnish Institute of Occupational Health and Imperial College London) have joined the Nanotechnology Industries Association (NIA) to boost project exploitation and dissemination.

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SmartNanoTox School and Combined Meeting in March 2018 Slovenia

SmartNanoTox satellite workshop/school on Advanced microscopy of nanomaterials and their interactions with living systems was organized in Ljubljana, Slovenia on the 19th and 20th of March 2018. The school comprised tutorials and hand-on training and was aimed at PhD students and Postdoctoral researches.

This project meeting followed the school on the 20th-23rd of March 2018 in Bohinj ECO Hotel, Slovenia. The meeting included thirty five participants involved in the project and five guests. Twenty five talks were presented during the meeting.

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A two-year Post Doctoral position is vacant as of 1 December 2017, at University of Lorraine, Nancy, France.

 

The framework of this job is defined by the Smartnanotox project.

This project has received funding from the European Union’s Horizon 2020 research and innovation programme under grant agreement No. 686098. Our participation in the project is to assess the toxicity of nanomaterials in vitro by transcriptome studies. We address main respiratory toxicity pathways for a representative set of nanomaterials, in identifying the molecular initiating events, the key events and the adverse outcome of these pathways. These data will be related to the physicochemical properties of the nanoparticles and will be of help to modelize bio/nano interrelationship by in silicio modelling.

The successful candidate will develop co-culture on the air-lung interface (ALI) system developed by Vitrocell® to assess the toxicity of relevant nanomaterials for the consortium. The candidate will be involved in intensive interdisciplinary collaborations with the 10 partners of the project. The housing team is moving for a very attractive environment at UMR-CNRS 7198, Institut Jean Lamour, one of the most famous French and European la on material sciences.

Educational qualifications
The applicant should have a completed PhD in cell biology, or toxicology.
We are seeking candidates with a background in cell biology. Favored practical skills involve coculture, cell toxicity assays. Air-liquid interface cell exposure system knowledge is an asset. An excellent English language proficiency is mandatory.

Contact Dr Olivier Joubert olivier.joubert@univ-lorraine.fr


Main publications of the group:

  • Elaboration of Sterically Stabilized Liposomes for S-Nitrosoglutathione Targeting to Macrophages. Diab R, Virriat AS, Ronzani C, Fontanay S, Grandemange S, Elaissari A, Foliguet B, Maincent P, Leroy P, Duvaj RE, Rihn BH, Joubert O. J Biomed Nanotechnol. 2016 Jan;12(1):217-30.
  • Comment on “Protein Corona Fingerprinting Predicts the Cellular Interaction of Gold and Silver
    Nanoparticles”. Rihn BH, Joubert O. ACS Nano. 2015 Jun 23;9(6):5634-5. doi: 10.1021/acsnano.5b00459.
  • Human monocyte response to S-nitrosoglutathione-loaded nanoparticles: uptake, viability, and
    transcriptome. Safar R, Ronzani C, Diab R, Chevrier J, Bensoussan D, Grandemange S, Le Faou A, Rihn BH, Joubert O. Mol Pharm. 2015 Feb 2;12(2):554-61. doi: 10.1021/mp5006382. Epub 2015 Jan 14.
  • Drug delivery by polymeric nanoparticles induces autophagy in macrophages. Eidi H, Joubert O, Némos C, Grandemange S, Mograbi B, Foliguet B, Tournebize J, Maincent P, Le Faou A, Aboukhamis I, Rihn BH. Int J Pharm. 2012 Jan 17;422(1-2):495-503. doi: 10.1016/j.ijpharm.2011.11.020. Epub 2011 Nov 22.